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defA [Mon Aug 31 2015 13:54:15 GMT+0200 (CEST)]
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defA [Mon Aug 31 2015 13:54:15 GMT+0200 (CEST)]

formylmethionine deformylase
locus
BSU15720
pI
4.00
mw
17.00 kDa
function
translation
product
formylmethionine deformylase
essential
no
ec
3.5.1.88
synonyms
yloK, def
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.12|Translation/ other]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.1|Protein maturation]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|protein modification]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,646,512 -> 1,646,994

    The protein

    Catalyzed reaction/ biological activity

  • Formyl-L-methionyl peptide H2O = formate methionyl peptide (according to Swiss-Prot)

    • Protein family

  • polypeptide deformylase family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|DefB]

    • [SW|Interactions]

  • [protein|search|DefA]-[protein|search|RplV] [Pubmed|18288106]
  • [protein|search|Map] competes with peptide deformylase ([protein|search|DefA]), the first enzyme to act on nascent chains, for binding sites at the ribosomal tunnel exit [Pubmed|23770820]

    • Expression and Regulation

    Operon

  • ''[protein|search|defA]-[protein|search|fmt]-[protein|search|yloM]'' [Pubmed|16964327]

    • [SW|Sigma factor]

  • [protein|search|SigA] ''[protein|search|defA]-[protein|search|fmt]-[protein|search|yloM]'' [Pubmed|16964327]

    • References

  • 11429456,12627383,18288106,16964327,23770820