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hepT [2019-07-04 12:54:45]
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hepT [2019-07-04 12:54:45]

heptaprenyl diphosphate synthase component II
Locus
BSU22740
Isoelectric point
6.28
Molecular weight
39.36 kDa
Protein length
348 aa Sequence Blast
Gene length
1047 bp Sequence Blast
Function
menaquinone biosynthesis
Product
heptaprenyl diphosphate synthase component II (together with HepS)
Essential
no
E.C.
2.5.1.30
Synonyms
gerCC,hepB,gerC58
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of menaquinone

    • Gene

    Coordinates
    2,381,919 2,382,965

    Phenotypes of a mutant

  • essential PubMed, non-essential according to PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • All-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate (according to Swiss-Prot)

    • Protein family

  • FPP/GGPP synthase family (with IspA, according to UniProt)

    • Paralogous protein(s)

  • YqiD

    • Structure

  • 5H9D (from Staphylococcus aureus, 47% identity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    hepS-menH-hepT-ndk
    Description
    PubMed
    view in new tab

    Biological materials

    Mutant

  • BKE22740 (hepT::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATCATTCACCCAAACATCTG, downstream forward: _UP4_TAATTTTTGTAGATATTAAG
  • BKK22740 (hepT::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATCATTCACCCAAACATCTG, downstream forward: _UP4_TAATTTTTGTAGATATTAAG

    • References

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