srfAB [Mon Aug 31 2015 13:52:25 GMT+0200 (CEST)]

surfactin synthetase / competence

Locus: BSU03490

Isoelectric point: 4.90

Molecular weight: 400.00 kDa

Function: antibiotic synthesis

Product: surfactin synthetase / competence

Essential: no

Synonyms: comL

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Lifestyles → Exponential and early post-exponential lifestyles → Swarming
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds
• Groups of genes → Membrane proteins
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue
• Groups of genes → Phosphoproteins → Phosphorylation on a Ser residue

Syns: comL

Categories containing this gene/protein

• miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, membrane proteins, phosphoproteins

This gene is a member of the following regulons

• Abh regulon, CodY regulon, ComA regulon, PerR regulon, Spx regulon

The protein

Protein family

• ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

Modification

• phosphorylation on Ser-999 AND Ser-2045 PubMed
• phosphorylated on Arg-1378 PubMed

Localization

• membrane PubMed

Expression and Regulation

Operon

• srfAA-srfAB-comS-srfAC-srfAD PubMed

Sigma factor

• SigA PubMed

Regulation

• repressed during growth in the presence of branched chain amino acids (CodY) PubMed
• repressed during hydrogen peroxide stress (PerR) PubMed
• expressed at high cell density (ComA) PubMed

Regulatory mechanism

• CodY: transcription repression PubMed
• ComA: transcription activation PubMed
• PerR: transcription activation PubMed
• Spx: transcription repression PubMed
• Abh: transcription repressionPubMed

References

Reviews

Loading

Original publications

Loading