manganese ABC transporter (binding protein, lipoprotein)
function
manganese uptake
product
manganese ABC transporter (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.6|Uptake of ions][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)]This gene is a member of the following [SW|regulons]
[SW|MntR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,145,038 -> 3,145,958
Phenotypes of a mutant
essential according to [http://www.ncbi.nlm.nih.gov/pubmed/17114254 Kobayashi et al.], but a mutant has been constructed and studied by [http://www.ncbi.nlm.nih.gov/pubmed/10760146 Que and Helmann, 2000]The protein
Protein family
bacterial solute-binding protein 9 family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|ZnuA][SW|Localization]
cell membrane (according to Swiss-Prot), extracellular lipoprotein (signal peptide) [Pubmed|18957862][SW|Interactions]
[protein|search|MntB]-([protein|search|MntC]-[protein|search|MntD])-[protein|search|MntA] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|mntA]-[protein|search|mntB]-[protein|search|mntC]-[protein|search|mntD]'' [Pubmed|10760146]Regulation
repressed at high Mn(II) concentrations ([protein|search|MntR]) [Pubmed|12950915]Regulatory mechanism
[protein|search|MntR]: transcription repression [Pubmed|12950915]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
10760146,10092453,12950915,10760146,18957862,10760146,17114254,20525796 
