murC

UDP-N-acetylmuramoyl-L-alanine synthetase

Locus: BSU_29790

Isoelectric point: 5.31

Molecular weight: 48.20 kDa

Protein length: 432 aa

Gene length: 1299 bp

Function: peptidoglycan precursor biosynthesis

Product: UDP-N-acetylmuramoyl-L-alanine synthetase

Essential: yes

E.C.: 6.3.2.8

Synonyms: ytxF

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Groups of genes → Essential genes

Gene

Coordinates: 3,048,177 3,049,475

Phenotypes of a mutant

• essential PubMed
• murC is dispensable in wall-less L-forms PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-alanine + UDP-N-acetyl-α-D-muramate --> ADP + H⁺ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanine (according to UniProt)

Protein family

• MurCDEF family (according to UniProt)

Structure

• 1GQQ (from Haemophilus influenzae, 31% identity)

Localization

• cytoplasm (Homogeneous) PubMed
• forms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed

Expression and Regulation

Operons

• Genes: murC
  Description: PubMed

• Genes: sftA-murC
  Description: PubMed

References

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