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yurJ [2019-09-02 12:54:30]
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yurJ [2019-09-02 12:54:30]

aminosugar ABC transporter (ATP-binding protein)
Locus
BSU_32550
Isoelectric point
6.07
Molecular weight
41.19 kDa
Protein length
367 aa Sequence Blast
Gene length
1104 bp Sequence Blast
Function
uptake of sugar amines
Product
aminosugar ABC transporter (ATP-binding protein)
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Importers → Uptake of carbon sources
  • Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of amino sugars
  • Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of amino sugars
  • Groups of genes → Membrane proteins
  • Groups of genes → Phosphoproteins → Phosphorylation on a Ser residue

    • Gene

    Coordinates
    3,345,013 3,346,116

    The protein

    Protein family

  • ABC transporter superfamily (according to UniProt)

    • Paralogous protein(s)

  • MsmX

    • Modification

  • phosphorylated on Ser-3 PubMed

    • Structure

  • 1G29 (from Thermococcus litoralis, 50% identity) PubMed

    • Localization

  • membrane associated (via FrlM-FrlN) PubMed

    • Expression and Regulation

    Operons

    Genes
    yurJ
    Description
    PubMed

    Regulatory mechanism

  • CodY: repression, PubMed, in CodY regulon
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    Genes
    frlB-frlO-frlN-frlM-frlD-yurJ
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • CodY: repression, PubMed, PubMed, in CodY regulon
  • FrlR: repression, PubMed, in FrlR regulon
  • YlxR: regulation, PubMed, in YlxR regulon

    • Regulation

  • FrlB: repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • induced in the absence of YlxR PubMed

    • Additional information

  • the frlB-frlO-frlN-frlM-frlD-yurJ operon is strongly downregulated in a cshA mutant PubMed
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    Biological materials

    Mutant

  • MGNA-A556 (yurJ::erm), available at the NBRP B. subtilis, Japan
  • BKE32550 (yurJ::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCAGAAAAGTCCCCCTAT, downstream forward: _UP4_TAGAAAAAGGTGCTCCTCAA
  • BKK32550 (yurJ::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCAGAAAAGTCCCCCTAT, downstream forward: _UP4_TAGAAAAAGGTGCTCCTCAA

    • References

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