pspA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

phage shock protein A homolog

locus: BSU06180

pI: 5.00

mw: 24.00 kDa

function: unknown

product: unknown

essential: no

synonyms: ydjF

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

[SW|Categories] containing this gene/protein

• [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|SigW regulon]

Gene

Coordinates on the chromosome (coding sequence): 671,245 -> 671,928

Phenotypes of a mutant

• more sensitive to nisin [Pubmed|23980836]

The protein

Protein family

• pspA/IM30 family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|LiaH]

[SW|Localization]

• membrane protein

Expression and Regulation

Operon

• ''[protein|search|pspA]-[protein|search|ydjG]-[protein|search|ydjH]-[protein|search|ydjI]'' [Pubmed|11454200]

[SW|Sigma factor]

• [protein|search|SigW] [Pubmed|11454200]

Regulation

• induced by alkaline shock ([protein|search|SigW]) [Pubmed|11454200]
• repressed during logarithmic phase ([protein|search|AbrB]) [Pubmed|18840696]
• induced by antibiotics interacting with the cytoplasmic membrane [Pubmed|22926563]
• induced by daptomycin [Pubmed|27791134]

Regulatory mechanism

• [protein|search|AbrB]: transcription repression [Pubmed|18840696]

References

• 11454200,18840696,22926563,23980836,27791134