class B penicillin-binding protein PBP 2A, required for cell wall synthesis during cell elongation
function
formation of a rod-shaped peptidoglycan cell wall, spore outgrowth
product
penicillin-binding protein PBP 2A
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.7|Penicillin-binding proteins][category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|penicillin-binding proteins]Gene
Coordinates on the chromosome (coding sequence)
2,581,771 -> 2,583,921
The protein
Catalyzed reaction/ biological activity
required for [SW|cell wall synthesis] during cell elongation [Pubmed|12896990]driver of [protein|search|MreB] dynamics [Pubmed|21636744,21636745][SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]localization depends on the availability of peptidoglyan precursors (lipid II) [Pubmed|23895585][SW|Interactions]
part of the [SW|elongasome] [Pubmed|21636744,21636745]folding requires [protein|search|PrsA] [Pubmed|20487272]Expression and Regulation
Operon
''[protein|search|pbpA]'' [Pubmed|21815947]Additional information
the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]Biological materials
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jeff Errington] labLabs working on this gene/protein
[SW|Jeff Errington], Newcastle University, UK [http://www.ncl.ac.uk/camb/staff/profile/jeff.errington homepage]References
9851991,9139922,12896990,18957862,20487272,21636744,21636745,21815947,23895585 
