spoIIT [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE

locus: BSU36770

pI: 6.00

mw: 28.00 kDa

function: control of SigE processing and activation

product: co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE

essential: no

synonyms: ywmB

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]

[SW|Categories] containing this gene/protein

• [SW|sporulation proteins]

This gene is a member of the following [SW|regulons]

• [SW|SigF regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,779,293 -> 3,780,033

Phenotype of a mutant

• mild sporulation defect due to inefficient activation of [SW|SigE] [Pubmed|26735940]
• inactivation of ''[SW|spoIIT]'' reduces sporulation efficiency to 38% that of wild type cells; abortively disporic [Pubmed|26735940]

The protein

Structure

• [PDB|2FPN]

[SW|Localization]

• secreted from the forespore to the intermembrane space between the forespore and the mother cell [Pubmed|26735940]

Expression and Regulation

Operon

• ''[SW|ywzB]-[SW|spoIIT]-[SW|murAA]'' [Pubmed|22383849]
• ''[SW|spoIIT]-[SW|murAA]'' [Pubmed|26735940]

[SW|Sigma factor]

• ''[SW|ywzB]'': [SW|SigA] [Pubmed|22383849]
• ''[SW|spoIIT]'': [SW|SigF] [Pubmed|26735940]

Regulation

• expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|26735940]

References

• 26735940,22383849,26735940