uvrA [Tue Jul 12 2016 11:14:58 GMT+0200 (CEST)]

excinuclease ABC (subunit A), required for transcription-dependent asymmetry in mutation rates of genes in the two orientations

locus: BSU35160

pI: 5.00

mw: 105.00 kDa

function: DNA repair after UV damage

product: excinuclease ABC (subunit A)

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination]
• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

This gene is a member of the following [SW|regulons]

• [SW|LexA regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,610,064 -> 3,612,937

The protein

Protein family

• UvrA subfamily (according to Swiss-Prot)

Structure

• [PDB|2R6F] (Geobacillus stearothermophilus)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|Mfd]-[protein|search|UvrA] [Pubmed|16464004]
• [protein|search|UvrA]-[protein|search|UvrB] [Pubmed|16464004]

Expression and Regulation

Operon

• ''[protein|search|uvrB]-[protein|search|uvrA]'' (according to [http://dbtbs.hgc.jp/COG/prom/uvrBA.html DBTBS])

Regulation

• induced upon DNA damage ([protein|search|LexA]) [Pubmed|8226626]

Regulatory mechanism

• [protein|search|LexA]: transcription repression [Pubmed|8226626]

Additional information

• during [protein|search|sporulation] expressed both in the forespore and the mother cell [PubMed|24118570]

References

Reviews

• 16464004,15927210,7801120,22933559

Original publications

• 11751826,21145481,8226626,24118570,24118570,25713353, 27399782