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spoIIAA [Fri Oct 16 2015 15:44:36 GMT+0200 (CEST)]
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spoIIAA [Fri Oct 16 2015 15:44:36 GMT+0200 (CEST)]

anti-anti-SigF
locus
BSU23470
pI
5.00
mw
12.00 kDa
function
control of SigF activity
product
anti-anti-SigF
essential
no
synonyms
Outlinks
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Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]

    • [SW|Categories] containing this gene/protein

  • [SW|sigma factors and their control], [SW|sporulation proteins], [SW|phosphoproteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|SigF regulon], [SW|SigG regulon], [SW|SigH regulon], [SW|SinR regulon], [SW|Spo0A regulon]

    • The protein

    Protein family

  • anti-sigma-factor antagonist family (according to Swiss-Prot)

    • Modification

  • phosphorylation on (Ser-58 OR Ser-59) by [SW|SpoIIAB][Pubmed|17218307], [Pubmed|16493705]

    • Structure

  • [PDB|1TIL] (complex with SpoIIAB, Geobacillus stearothermophilus), [PDB|1AUZ] (NMR)

    • [SW|Interactions]

  • [SW|SpoIIAB]-[SW|SpoIIAA] [Pubmed|15201047]

    • Expression and Regulation

    Operon

  • ''[protein|search|dacF]-[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]
  • ''[SW|spoIIAA]-[SW|spoIIAB]-[protein|search|sigF]'' [Pubmed|22383849]

    • [SW|Sigma factor]

  • ''[protein|search|dacF]'': [protein|search|SigF], [protein|search|SigG]
  • ''[SW|spoIIAA]'': [protein|search|SigH]

    • Regulation

  • repressed by glucose (5.2-fold) [Pubmed|12850135], ''[protein|search|dacF]'': expressed during sporulation, ''[SW|spoIIAA]'': expressed early during sporulation
  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/1556084,15687200 PubMed]

    • Regulatory mechanism

  • ''[SW|spoIIAA]'': activated by [SW|Spo0A] and repressed by [protein|search|SinR]
  • [SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/1556084,15687200 PubMed]
  • [protein|search|AbrB]: transcription repression [Pubmed|20817675]

    • Labs working on this gene/protein

  • [SW|Tony Wilkinson], York University, U.K. [http://www.york.ac.uk/depts/chem/staff/ajw.html homepage]
  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

    • References

    Modeling of [protein|search|SigF] activation

  • 24067622,22312331,20298743

    • Original Publications

  • 1391042,8358793,8955289,15023063,15351644,9077448,10323866,8820658,8622920,16824103,7570023,10476035,8932322,8764398,8764397,12676949,9826498,9826499,14744853,9642177,11684022,8846916,11298272,1948031,3114419,11846550,15201047,2123551,8168129,1556084,15687200,12850135,16493705,17218307,10049355,20817675