ylmB [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

locus: BSU15350

pI: 4.98

mw: 47.00 kDa

function: thiamine salvage

product: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|Thi-box]

Gene

Coordinates on the chromosome (coding sequence): 1,607,556 -> 1,608,836

The protein

Catalyzed reaction/ biological activity

• N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine + H2O = formate + 4-amino-5-aminomethyl-2-methylpyrimidine (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YodQ]

[SW|Cofactors]

• Binds 2 zinc or cobalt ions per subunit (according to Swiss-Prot)

Expression and Regulation

Regulation

• repressed by thiamine ([protein|search|Thi-box]) [Pubmed|12376536]

Regulatory mechanism

• [protein|search|Thi-box]: [SW|RNA switch] [Pubmed|12376536]

References

• 17618314,12376536