oligopeptide ABC transporter (ATP-binding protein)
function
initiation of sporulation, competence development
product
oligopeptide ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.3|Uptake of peptides][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|utilization of nitrogen sources other than amino acids], [SW|genetic competence], [SW|phosphorelay], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ScoC regulon], [SW|TnrA regulon]Gene
Coordinates on the chromosome (coding sequence)
1,224,533 -> 1,225,450
The protein
Catalyzed reaction/ biological activity
required for the uptake of quorum sensing peptides such as [protein|search|PhrH] [Pubmed|21908671]Protein family
[SW|ABC transporter] domain (according to Swiss-Prot)[SW|Localization]
attached to the cell membrane (via [protein|search|OppB]-[protein|search|OppC]) [Pubmed|10092453][SW|Interactions]
([protein|search|OppD]-[protein|search|OppF])-([protein|search|OppB]-[protein|search|OppC])-[protein|search|OppA] [Pubmed|10092453]Expression and Regulation
Operon
''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'' [Pubmed|1901616]Regulation
expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]repressed during exponential growth ([protein|search|ScoC]) [Pubmed|10383984]Regulatory mechanism
[protein|search|TnrA]: transcription activation [Pubmed|12823818][protein|search|ScoC]: transcription repression [Pubmed|10383984][protein|search|CodY]: transcription repression, no derepression occurs, however, in a ''[protein|search|codY]'' mutant, due to increased repression by [protein|search|ScoC] [Pubmed|25966844]Biological materials
Mutant
GP2097 (D(''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'')::''aphA3''), available in [SW|Jörg Stülke]'s labReferences
12823818,1901616,10092453,9252573,1899858,21908671,12823818,10383984,25966844,25755103 
