yoaD [2017-05-09 15:36:34]

similar to phosphoglycerate dehydrogenase

Locus: BSU18560

Isoelectric point: 5.62

Molecular weight: 38.47 kDa

Protein length: 344 aa

Gene length: 1032 bp

Function: methionine biosynthesis

Product: unknown

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of methionine/ S-adenosylmethionine/ based on similarity

Gene

Coordinates: 2,024,042 → 2,025,076

The protein

Catalyzed reaction/ biological activity

• YoaD is likely to convert 3-phosphoglycerate to serine for use in methionine biosynthesis (based on S-box regulation)

Additional information

• The gene is annotated in KEGG as an ortholog of D-3-phosphoglycerate dehydrogenase EC 1.1.1.95. No EC annotation is available in Swiss-Prot. In MetaCyc the protein is marked as “similar to phosphorglycerate dehydrogenase”. No literature/experimental evidence supporting the annotation is available. PubMed

Expression and Regulation

Operons

• Genes: yoaD-yoaC-yoaB
  Description: PubMed

  Regulatory mechanism

  • S-box: termination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed, in S-box

  Regulation

  • induced by methionine starvation (S-box) PubMed
  • the S-box RNA is degraded by RNase Y PubMed

Biological materials

Mutant

• MGNA-A835 (yoaD::erm), available at the NBRP B. subtilis, Japan

References

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