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sigA [Fri Jan 29 2016 15:57:31 GMT+0100 (CET)]
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sigA [Fri Jan 29 2016 15:57:31 GMT+0100 (CET)]

RNA polymerase major sigma factor SigA
locus
BSU25200
pI
4.00
mw
42.00 kDa
function
transcription
product
RNA polymerase major sigma factor SigA
essential
yes
synonyms
rpoD, crsA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.1|Transcription] → [category|SW 3.2.1.2|Sigma factors]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.1|Sigma factors]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • [SW|Categories] containing this gene/protein

  • [SW|transcription], [SW|sigma factors and their control], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|SigD regulon], [SW|SigH regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,600,214 -> 2,601,329

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Protein family

  • sigma-70 factor family (according to Swiss-Prot)

    • Structure

  • [PDB|3IYD] ([SW|RNA polymerase] from ''E. coli'', 69% identity) [Pubmed|19903881]

    • [SW|Localization]

  • cytoplasm [Pubmed|25313396]

    • [SW|Interactions]

  • [SW|Spo0A]-[protein|search|SigA] [Pubmed|14976210]
  • [protein|search|SigA]-([protein|search|RpoB]-[protein|search|RpoC]) [Pubmed|19680289,19735077]
  • [protein|search|BsrA]-[protein|search|SigA]-[SW|RNA polymerase]
  • [protein|search|BsrB]-[protein|search|SigA]-[SW|RNA polymerase]
  • [SW|ComA]-[SW|SigA] [Pubmed|26582911]

    • Expression and Regulation

    Operon

  • ''[protein|search|yqxD]-[protein|search|dnaG]-[protein|search|sigA]'' [Pubmed|3298998]
  • ''[protein|search|sigA]'' [Pubmed|3919021]

    • [SW|Sigma factor]

  • ''[protein|search|yqxD]'': [protein|search|SigA] [Pubmed|3298998], [protein|search|SigH] [Pubmed|3127379]
  • ''[protein|search|sigA]'': [protein|search|SigD] [Pubmed|3919021]

    • Additional information

  • An [ncRNA|search|antisense RNA] is predicted for '[protein|search|sigA]' [PubMed|20525796]

    • Labs working on this gene/protein

  • [SW|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]

    • References

    Reviews

  • 22210308,24308327

    • Original publications

  • 12486038,10556308,8107087,14762002,7918363,8071196,7630711,9185571,9287022,14679239,14976210,19735077,2997585,9658000,3127379,10438769,11535782,7599136,9144176,19680289,20525796,22333917,20935043,20817769,23875654,25112476,26582911,19903881