manganese transporter (proton symport)
function
manganese uptake
product
manganese transporter (proton symport))
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|transporters/ other], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|MntR regulon]Gene
Coordinates on the chromosome (coding sequence)
491,147 -> 492,424
The protein
Protein family
NRAMP family (according to Swiss-Prot)Structure
[PDB|4WGV] (from ''Staphylococcus capitis'', 40% identity) [Pubmed|25326704][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''mntH'' [Pubmed|10760146]Regulation
repressed by Mn(2) ([protein|search|MntR]) [Pubmed|10760146]repressed at high Mn(II) concentrations (MntR) [Pubmed|10760146] Regulatory mechanism
MntR: transcription repression [Pubmed|10760146][protein|search|MntR]: transcription repression [Pubmed|10760146]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
10760146,12950915,10760146,25326704 
