SubtiBank SubtiBank
adhA
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adhA

thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins
Locus
BSU_27010
Isoelectric point
5.37
Molecular weight
37.67 kDa
Protein length
349 aa Sequence Blast
Gene length
1050 bp Sequence Blast
Function
response to toxic formaldehyde
Product
thiol-dependent aldehyde dehydrogenase, reduction of aldehydes
Essential
no
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

    • Gene

    Coordinates
    2,756,312 2,757,361

    The protein

    Protein family

  • zinc-containing alcohol dehydrogenase family (according to UniProt)

    • Structure

  • 1UUF (from E. coli, 54% identity)

    • Expression and Regulation

    Operons

    Genes
    yrzP-adhA-yraA
    Description
    PubMed
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    Genes
    adhA-yraA
    Description
    PubMed

    Regulatory mechanism

  • AdhR: activation, PubMed, in AdhR regulon

    • Regulation

  • adhA: induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed
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    Biological materials

    Mutant

  • MGNA-A260 (adhA::erm), available at the NBRP B. subtilis, Japan
  • BKE27010 (adhA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATACGAACCTATCCTTTCT, downstream forward: _UP4_TAATAGGTTAGTCCTTATAT
  • BKK27010 (adhA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATACGAACCTATCCTTTCT, downstream forward: _UP4_TAATAGGTTAGTCCTTATAT

    • References

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