gmuF [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

mannose-6-P-isomerase

locus: BSU05870

pI: 5.90

mw: 35.00 kDa

function: glucomannan utilization

product: mannose-6-P-isomerase

essential: no

synonyms: ydhS

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.25|Utilization of glucomannan]

[SW|Categories] containing this gene/protein

• [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|AbrB regulon], [SW|CcpA regulon], [SW|GmuR regulon]

Gene

Coordinates on the chromosome (coding sequence): 631,808 -> 632,755

Expression and Regulation

Operon

• ''[protein|search|gmuB]-[protein|search|gmuA]-[protein|search|gmuC]-[protein|search|gmuD]-[protein|search|gmuR]-[protein|search|gmuE]-[protein|search|gmuF]-[protein|search|gmuG]'' [Pubmed|18177310]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|18177310]

Regulation

• induced by conjac glucomannan (requires [protein|search|GmuG]) ([protein|search|GmuR]) [Pubmed|18177310]
• induced by cellobiose ([protein|search|GmuR]) [Pubmed|18177310]
• subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|18177310]

Regulatory mechanism

• [protein|search|GmuR]: transcription repression [Pubmed|18177310]
• [protein|search|CcpA]: transcription repression [Pubmed|18177310]
• [protein|search|AbrB]: transcription activation [Pubmed|20817675]

References

• 18177310,19447949,20817675