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menA
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
function
biosynthesis of menaquinone
product
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.8|Biosynthesis of menaquinone][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,950,726 3,951,661
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate + H+ --> 2-demethylmenaquinol + CO2 + diphosphate (according to UniProt)Protein family
MenA family (single member, according to UniProt)Structure
[PDB|3BYV] (from ''Toxoplasma gondii'', 30% identity in a 25% fragment) [Pubmed|19197235][SW|Localization]
cell membrane (according to UniProt)Expression and Regulation
Operons
genes
[gene|34DBBDD76A0B36867E5116FF17391DF70062F745|menA]
description
[Pubmed|9353933]
regulation
the leader mRNA is processed by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|YmcA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|YlbF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|YaaT] complex [Pubmed|29794222]view in new tabBiological materials
Mutant
MGNA-B217 (ywaB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1216 NBRP B. subtilis, Japan]References
325275279353933,19197235,29794222