papA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

Xaa-Pro amino-peptidase

locus: BSU24460

pI: 4.00

mw: 37.00 kDa

function: degradation of proline-containing peptides

product: Xaa-Pro amino-peptidase

essential: no

ec: 3.4.11.9

synonyms: yqhT

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]

[SW|Categories] containing this gene/protein

• [SW|utilization of nitrogen sources other than amino acids], [SW|coping with hyper-osmotic stress], [SW|sporulation/ other]

Gene

Coordinates on the chromosome (coding sequence): 2,538,697 -> 2,539,758

Phenotypes of a mutant

• inactivation of ''[SW|papA]'' reduces sporulation efficiency to 1.2% that of wild type cells; delayed entry into sporulation [Pubmed|26735940]

The protein

Protein family

• peptidase M24B family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|PapB]

Structure

• [PDB|3Q6D] (the ''B. anthracis'' enzyme, 65% identity, 82% similarity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Biological materials

Mutant

• available in the [SW|Erhard Bremer] lab

Labs working on this gene/protein

• [SW|Erhard Bremer], Marburg University, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi Homepage]

References

• 23144141,26735940