mtnB [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

methylthioribulose-1-phosphate dehydratase

locus: BSU13610

pI: 5.69

mw: 23.00 kDa

function: methionine salvage

product: methylthioribulose-1-phosphate dehydratase

essential: no

ec: 4.2.1.109

synonyms: ykrY

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|S-box]

Gene

Coordinates on the chromosome (coding sequence): 1,428,940 -> 1,429,569

The protein

Catalyzed reaction/ biological activity

• S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H₂O (according to Swiss-Prot)

Protein family

• MtnB subfamily (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|mtnW]-[protein|search|mtnX]-[protein|search|mtnB]-[protein|search|mtnD]'' [Pubmed|12022921]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12022921]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

Regulatory mechanism

• [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]

References

• 12022921,11914366,12107147,15102328,12787499,18039762