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hemD [2019-08-08 10:13:43]
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hemD [2019-08-08 10:13:43]

uroporphyrinogen-III synthase
locus
BSU_28140
pI
5.09
mw
28.96 kDa
protein length
262 aa Sequence Blast
gene length
789 bp Sequence Blast
function
heme biosynthesis
product
uroporphyrinogen-III synthase
essential
no
ec
4.2.1.75
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • Gene

    Coordinates
    2,875,173 2,875,961

    The protein

    Catalyzed reaction/ biological activity

  • Hydroxymethylbilane = uroporphyrinogen III + H2O (according to Swiss-Prot)

    • Protein family

  • uroporphyrinogen-III synthase family (single member, according to UniProt)

    • Expression and Regulation

    Operons

    count
    2
    genes
    [gene|B1413EB525000744BE8E429E760220A13BC4530D|hemA]-[gene|88616BA1E853E11BE0CB18F06287CA4C68143148|hemX]-[gene|D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B|hemC]-[gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]-[gene|70263A55987F110209367CF45AD65A584AD3077D|hemB]-[gene|A54B2C86638D474F5F892003B42C535B5B39A42E|hemL]
    description
    [Pubmed|1672867]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1672867], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR]: repression, [Pubmed|11532148], in [regulon|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR regulon]

    • regulation

  • induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]
    • view in new tab

    Biological materials

    Mutant

  • BKE28140 ([gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE28140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG, downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG
  • BKK28140 ([gene|33459D4389F85D60311FCE770BBA0ED9802BA342|hemD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK28140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTTTCCTTTCAACG, downstream forward: _UP4_ATGTCAAGAGAGGAAGAGAG

    • References

    Reviews

  • 28123057

    • Original Publications

  • 10217486,1672867,7628476,11532148,22960854