hemD [Mon Aug 31 2015 13:56:04 GMT+0200 (CEST)]

uroporphyrinogen-III synthase

locus: BSU28140

pI: 5.09

mw: 28.00 kDa

function: heme biosynthesis

product: uroporphyrinogen-III synthase

essential: no

ec: 4.2.1.75

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|PerR regulon]

The protein

Catalyzed reaction/ biological activity

• Hydroxymethylbilane = uroporphyrinogen III + H₂O (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|hemA]-[protein|search|hemX]-[protein|search|hemC]-[protein|search|hemD]-[protein|search|hemB]-[protein|search|hemL]'' [Pubmed|1672867]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|1672867]

Regulation

• induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

Regulatory mechanism

• [protein|search|PerR]: transcription repression [Pubmed|11532148]

References

• 10217486,1672867,7628476,11532148,22960854