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hemD [2017-09-04 17:02:02]
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hemD [2017-09-04 17:02:02]

uroporphyrinogen-III synthase
Locus
BSU28140
Isoelectric point
5.09
Molecular weight
28.96 kDa
Protein length
262 aa Sequence Blast
Gene length
786 bp Sequence Blast
Function
heme biosynthesis
Product
uroporphyrinogen-III synthase
Essential
no
E.C.
4.2.1.75
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of heme/ siroheme

    • Gene

    Coordinates
    2,875,173 → 2,875,961

    The protein

    Catalyzed reaction/ biological activity

  • Hydroxymethylbilane = uroporphyrinogen III + H2O (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Count
    2
    Genes
    hemA-hemX-hemC-hemD-hemB-hemL
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • PerR: repression, PubMed, in PerR regulon

    • Regulation

  • induced by hydrogen peroxide (PerR) PubMed
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    References

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