mecA [Mon Aug 31 2015 13:53:39 GMT+0200 (CEST)]

buffering protein for development, dampens transitions to spore, biofilm exopolysaccharide and competence expression , targets ComK and ComS to ClpC-ClpP degradation machine (in log Phase), inhibits the transcriptional activity of Spo0A?P by direct interaction

Locus: BSU11520

Isoelectric point: 4.00

Molecular weight: 25.00 kDa

Function: control of ComK degradation, regulation of competence

Product: adaptor protein

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → Genetic competence
• Information processing → Protein synthesis, modification and degradation → Proteolysis → Additional proteins involved in proteolysis
• Lifestyles → Exponential and early post-exponential lifestyles → Genetic competence

Categories containing this gene/protein

• genetic competence, proteolysis

Gene

Coordinates on the chromosome (coding sequence): 1,229,068 -> 1,229,724

The protein

Protein family

• mecA family (according to Swiss-Prot)

Paralogous protein(s)

• YpbH

Domains

• N-terminal domain (1 ... 120): recruitment of protein substrates PubMed
• C-terminal domain (121 ... 218): facilitates assembly of the ClpC-ClpP oligomer and acts as a degradation tag PubMed

Structure

• 3JTP (C-terminal domain) PubMed
• 3PXG, [PDB|3J3U 3J3U] (the MecA-ClpC complex) PubMed

Interactions

• MecA-ComK PubMed
• MecA-ComS PubMed
• ClpC-MecA PubMed
• MecA-Spo0A PubMed

Expression and Regulation

Operon

• mecA PubMed

Sigma factor

• SigA PubMed

Biological materials

Mutant

• GP813 (spc), GP814 (aphA3) both available in the Stülke lab

References

Reviews

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Original Publications

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