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appD [Mon Aug 31 2015 13:53:37 GMT+0200 (CEST)]
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appD [Mon Aug 31 2015 13:53:37 GMT+0200 (CEST)]

oligopeptide ABC transporter (ATP-binding protein)
locus
BSU11360
pI
5.39
mw
36.00 kDa
function
uptake of oligopeptides
product
oligopeptide ABC transporter (ATP-binding protein))
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.3|Uptake of peptides]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|utilization of nitrogen sources other than amino acids], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CodY regulon], [SW|ScoC regulon], [SW|TnrA regulon]

    • The protein

    Protein family

  • [SW|ABC transporter] domain (according to Swiss-Prot)

    • [SW|Localization]

  • attached to the cell membrane (via [protein|search|AppB]-[protein|search|AppC]) [Pubmed|10092453]

    • [SW|Interactions]

  • ([protein|search|AppD]-[protein|search|AppF])-([protein|search|AppB]-[protein|search|AppC])-[protein|search|AppA] [Pubmed|10092453]

    • Expression and Regulation

    Operon

  • ''[protein|search|appD]-[protein|search|appF]-[protein|search|appA]-[protein|search|appB]-[protein|search|appC]'' [Pubmed|7997159]

    • Regulation

  • repressed by [protein|search|CodY] [Pubmed|12618455]
  • repressed during exponential growth ([protein|search|ScoC]) [Pubmed|10383984]
  • repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]

    • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/18083814 PubMed2]
  • [protein|search|ScoC]: transcription repression [Pubmed|10383984]
  • [protein|search|TnrA]: transcription activation [Pubmed|25755103]

    • Biological materials

    Mutant

  • GP2100 (D(''[protein|search|appD]-[protein|search|appF]-[protein|search|appA]-[protein|search|appB]-[protein|search|appC]'')::''spc''), available in [SW|Jörg Stülke]'s lab

    • References

  • 18083814,12618455,7997159,10092453,10383984,12618455,25755103