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ylmE [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]
enzyme involved in controlling the availability of coenzyme A
function
control of the CoA pool
Genomic Context
categories
[category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes][SW|Categories] containing this gene/protein
[SW|poorly characterized/ putative enzymes]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,610,170 -> 1,610,862
The protein
Catalyzed reaction/ biological activity
while the protein was described as an amino acid racemase important for biofilm formation [Pubmed|20431016], no racemase activity was detected in ''in vitro'' assays with a functionally active protein [Pubmed|24097949]Protein family
UPF0001 family (according to Swiss-Prot)[SW|Cofactors]
pyridoxal phosphate [Pubmed|24097949]Structure
[PDB|1W8G] (the structure of YggS from ''E. coli'' 33% identity, 61% similarity)Expression and Regulation
Operon
''[protein|search|ylmD]-[protein|search|ylmE]-[protein|search|sepF]-[protein|search|ylmG]-[protein|search|ylmH]'' [Pubmed|16420366]Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]References
14651647,16420366,24097949,26872910 
