cystathionine lyase/ homocysteine gamma-lyase
function
methionine-to-cysteine conversion
product
cystathionine lyase/ homocysteine gamma-lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CymR regulon], [SW|Spx regulon]Gene
Coordinates on the chromosome (coding sequence)
2,785,001 -> 2,786,140
The protein
Catalyzed reaction/ biological activity
L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (according to Swiss-Prot)Protein family
trans-sulfuration enzymes family (according to Swiss-Prot)[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|yrrT]-[protein|search|mtnN]-[protein|search|mccA]-[protein|search|mccB]-[protein|search|yrhC]'' [Pubmed|17056751][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16513748]Regulation
repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16513748]Regulatory mechanism
[protein|search|CymR]: transcription repression [Pubmed|16513748][protein|search|Spx]: transcription activation [Pubmed|12642660,16885442]Biological materials
Mutant
1A942 ( ''mccB''::''kan''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A942&Search=1A942 BGSC]1A945 ( ''mccB''::''kan''), [Pubmed|17056751], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A945&Search=1A945 BGSC]References
17056751,16513748,16885442,12642660 
