aag [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

hypoxanthine-DNA glycosylase, general stress protein, required for protection against paraquat stress

Locus: BSU38620

Isoelectric point: 6.00

Molecular weight: 21.00 kDa

Function: DNA repair, survival of stress conditions

Product: hypoxanthine-DNA glycosylase

Essential: no

Synonyms: yxlJ

Genomic Context

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Categories containing this gene/protein

• Information processing → Genetics → DNA repair/ recombination/ based on similarity
• Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
• Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

Categories containing this gene/protein

• DNA repair/ recombination, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

• SigB regulon, SigG regulon

Gene

Coordinates on the chromosome (coding sequence): 3,964,278 -> 3,964,868

Phenotypes of a mutant

• increased sensitivity of sporulating cells to the genotoxic effects of MMS PubMed

The protein

Catalyzed reaction/ biological activity

• removes hypoxanthine, 3-alkylated purines, and 1,N6-ethenoadenine from DNA; hypoxanthine and 1,N6-ethenoadenine are the preferred substrates PubMed
• protects sporulating cells from cytotoxic and genotoxic effects of MMS PubMed

Protein family

• DNA glycosylase MPG family (according to Swiss-Prot) AAG family of 3-methyladenine DNA glycosylases

Localization

• forespore PubMed

Expression and Regulation

Operon

• aag-yxzF PubMed

Sigma factor

• SigB PubMed
• SigG PubMed

Regulation

• induced by stress (SigB) PubMed
• expressed late during sporulation in the forespore SigG PubMed

References

Reviews

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Original publications

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