hypoxanthine-DNA glycosylase, general stress protein, required for protection against paraquat stress
function
DNA repair, survival of stress conditions
product
hypoxanthine-DNA glycosylase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.6|DNA repair/ recombination/ based on similarity][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|general stress proteins (controlled by SigB)], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|SigB regulon], [SW|SigG regulon]Gene
Coordinates on the chromosome (coding sequence)
3,964,278 -> 3,964,868
Phenotypes of a mutant
increased sensitivity of sporulating cells to the genotoxic effects of MMS [Pubmed|27698084]The protein
Catalyzed reaction/ biological activity
removes hypoxanthine, 3-alkylated purines, and 1,N6-ethenoadenine from DNA; hypoxanthine and 1,N6-ethenoadenine are the preferred substrates [Pubmed|14729667]protects sporulating cells from cytotoxic and genotoxic effects of MMS [Pubmed|27698084]Protein family
DNA glycosylase MPG family (according to Swiss-Prot) AAG family of 3-methyladenine DNA glycosylases[SW|Localization]
forespore [Pubmed|27698084]Expression and Regulation
Operon
''[protein|search|aag]-[protein|search|yxzF]'' [Pubmed|8990303][SW|Sigma factor]
[protein|search|SigB] [Pubmed|11544224][SW|SigG] [Pubmed|27698084]Regulation
induced by stress ([protein|search|SigB]) [Pubmed|11544224]expressed late during [SW|sporulation] in the forespore [SW|SigG] [Pubmed|27698084]References
Reviews
Original publications
15805528,14729667,22582280,27698084 
