oligopeptide ABC transporter (binding protein)
function
initiation of sporulation, competence development
product
oligopeptide ABC transporter (binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.3|Uptake of peptides][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.4|Utilization of peptides][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.6|Phosphorylation on a Thr residue][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.7|Phosphorylation on a Tyr residue][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|utilization of nitrogen sources other than amino acids], [SW|genetic competence], [SW|phosphorelay], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ScoC regulon], [SW|TnrA regulon]Gene
Coordinates on the chromosome (coding sequence)
1,219,849 -> 1,221,486
The protein
Catalyzed reaction/ biological activity
required for the uptake of quorum sensing peptides such as [protein|search|PhrH] [Pubmed|21908671]Protein family
bacterial solute-binding protein 5 family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|DppE]Modification
phosphorylation on (Tyr-301 OR Tyr-303) AND Thr-470 [Pubmed|17218307][SW|Localization]
attached to the cell membrane (via [protein|search|OppB]-[protein|search|OppC]) [Pubmed|10092453]at the outer side of the cell: extracellular (signal peptide) [Pubmed|18957862], lipid modification as retention signal [Pubmed|18763711][SW|Interactions]
([protein|search|OppD]-[protein|search|OppF])-([protein|search|OppB]-[protein|search|OppC])-[protein|search|OppA] [Pubmed|10092453][protein|search|FloT]-[protein|search|OppA] [Pubmed|23651456]Expression and Regulation
Operon
''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'' [Pubmed|1901616]Regulation
expressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|12823818]repressed during exponential growth ([protein|search|ScoC]) [Pubmed|10383984]Regulatory mechanism
[protein|search|TnrA]: transcription activation [Pubmed|12823818][protein|search|ScoC]: transcription repression [Pubmed|10383984][protein|search|CodY]: transcription repression, no derepression occurs, however, in a ''[protein|search|codY]'' mutant, due to increased repression by [protein|search|ScoC] [Pubmed|25966844]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|trpS]' and '[protein|search|oppA]' [PubMed|20525796]Biological materials
Mutant
BP67 (spc) available in [SW|Fabian Commichau]'s lab1S118 ( ''oppA''::''spec''), [Pubmed|11267663], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1S118&Search=1S118 BGSC]GP2097 (D(''[protein|search|oppA]-[protein|search|oppB]-[protein|search|oppC]-[protein|search|oppD]-[protein|search|oppF]'')::''aphA3''), available in [SW|Jörg Stülke]'s labBKE11430 (''[protein|search|oppA]''::''erm'', available in the BGSC, in [SW|Fabian Commichau]'s, and in [SW|Jörg Stülke]'s lab)References
1901616,10092453,12823818,11267663,9252573,10960106,12823818,10383984,18957862,18763711,17218307,7997159,20525796,23651456,21908671,25755103,25966844,1899858,23199363 
