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dltE
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dltE

D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides
Locus
BSU_38540
Isoelectric point
5.09
Molecular weight
28.12 kDa
Protein length
252 aa Sequence Blast
Gene length
759 bp Sequence Blast
Function
biosynthesis of teichoic acid
Product
D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain
Essential
no
Synonyms
ipa-1r

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
3,956,492 3,957,250

Phenotypes of a mutant

  • more sensitive to nisin PubMed
  • The protein

    Protein family

    Structure

  • 5FF9 (28% identity) PubMed
  • Localization

  • cytoplasm (according to UniProt)
  • Expression and Regulation

    Operons

    Description

    Sigma factors

  • SigD: sigma factor, PubMed, in SigD regulon
  • SigM: sigma factor, PubMed, in SigM regulon
  • SigX: sigma factor, PubMed, in SigX regulon
  • SigV: sigma factor, PubMed, in SigV regulon
  • Regulatory mechanism

  • YvrHb: activation, PubMed, in YvrHb regulon
  • Spo0A: repression, PubMed, in Spo0A regulon
  • stringent response: negative regulation, in stringent response
  • Regulation

  • expression is reduced in a SigV mutant PubMed
  • the mRNA is processed between ywzH and dltA by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed
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    Biological materials

    Mutant

  • BKE38540 (dltE::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGGATGTAACACCTCTT, downstream forward: _UP4_TAATTTCTCCTGCTTTTTTC
  • BKK38540 (dltE::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGGATGTAACACCTCTT, downstream forward: _UP4_TAATTTCTCCTGCTTTTTTC
  • References

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