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mmgF
Molecular weight
32.94 kDa
Function
mother cell metabolism
Product
methylisocitrate lyase
Genomic Context
Categories containing this gene/protein
Gene
Coordinates
2,507,298 2,508,203
The protein
Catalyzed reaction/ biological activity
2-methyl-isocitrate --> pyruvate + succinate PubMed3-hydroxybutane-1,2,3-tricarboxylate --> pyruvate + succinate (according to UniProt) Protein family
isocitrate lyase/PEP mutase superfamily (single member, according to UniProt)Structure
1MUM (enzyme of E. coli), 3KZ2 (the enzyme from B. anthracis) Expression and Regulation
Operons
Sigma factors
Regulatory mechanism
Regulation
expressed early during sporulation in the mother cell (SigE) PubMedstrongly expressed during oligotrophic growth PubMed view in new tabBiological materials
Mutant
MGNA-C374 (yqiQ::erm), available at the NBRP B. subtilis, JapanBKE24120 (mmgF::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGACATGAAACAAAATCCCC, downstream forward: _UP4_TAATGCAACAAAAAAAGCCGBKK24120 (mmgF::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGACATGAAACAAAATCCCC, downstream forward: _UP4_TAATGCAACAAAAAAAGCCG References
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