SubtiBank SubtiBank
ndoA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

ndoA [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

RNase EndoA, MazF family toxin, UACAU-specific mRNA interferase
locus
BSU04660
pI
4.89
mw
12.00 kDa
function
unknown
product
mRNA interferase
essential
no
synonyms
ydcE, mazF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.2|Endoribonucleases]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.2|Type 2 TA systems]
    • syns
    ydcE, mazF

    [SW|Categories] containing this gene/protein

  • [SW|RNAses], [SW|toxins, antitoxins and immunity against toxins]

    • The protein

    Catalyzed reaction/ biological activity

  • specifically cleaves a five-base sequence, UACAU [Pubmed|21763692]

    • Protein family

  • pemK family (according to Swiss-Prot)

    • Effectors of protein activity

  • the activity is inhibited by the interaction with [SW|NdoAI] [Pubmed|17416361]

    • Structure

  • [PDB|1NE8] [Pubmed|14517982]
  • [PDB|4MDX] (NdoA-RNA) [Pubmed|24120662]
  • [PDB|4ME7] ([protein|search|NdoA]-[SW|NdoAI] complex) [Pubmed|24120662]

    • [SW|Interactions]

  • [protein|search|NdoA](2)-[SW|NdoAI](2)-[protein|search|NdoA](2) [Pubmed|24120662,17416361]
  • the active protein forms dimers [Pubmed|24120662]

    • Expression and Regulation

    Operon

  • ''[SW|ndoAI]-[protein|search|ndoA]'' [Pubmed|15882409]

    • References

  • 15882409,17416361,20525796,21763692,21897862,23378533,14517982,24120662,24489751,23736285