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pgsA [2019-08-01 11:22:03]
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pgsA [2019-08-01 11:22:03]

phosphatidylglycerophosphate synthase
locus
BSU_16920
pI
5.16
mw
21.16 kDa
protein length
193 aa Sequence Blast
gene length
582 bp Sequence Blast
function
biosynthesis of phospholipids
product
phosphatidylglycerophosphate synthase
essential
yes
ec
2.7.8.5
synonyms
ymfN
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,762,623 1,763,204

    Phenotypes of a mutant

  • some point mutations resulting in reduced PgsA activity lead to daptomycin resistance [Pubmed|21709092]essential [Pubmed|12682299]
  • depletion leads to hypersensitivity to sorbic acid stress [Pubmed|27818647]

    • The protein

    Catalyzed reaction/ biological activity

  • CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot)

    • Protein family

  • CDP-alcohol phosphatidyltransferase class-I family (with [protein|DE49797486CEC172F912D26A6BF2223190BF5DAD|PssA], according to UniProt)

    • [SW|Localization]

  • cell membrane at the septum [Pubmed|19820159,15743965]

    • Biological materials

    Mutant

  • 1A815 ( ''pgsA''::''erm''), [Pubmed|12682299], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A815&Search=1A815 BGSC]

    • References

  • 19745567,16514141,19820159,15743965,21709092,27818647