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dtrR
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dtrR

D-Tyr resistance regulator ([SW|MarR family])
locus
BSU_38450
pI
8.76
mw
19.50 kDa
protein length
171 aa Sequence Blast
gene length
516 bp Sequence Blast
function
resistance to D-Tyr
product
transcription factor ([SW|MarR family])
essential
no
synonyms
ywaE,ipa-10r
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • Gene

    Coordinates
    3,946,394 3,946,909

    The protein

    Catalyzed reaction/ biological activity

  • repression of the ''[gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]-[gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ]'' operon [Pubmed|25733610]

    • Protein family

  • [SW|MarR family]

    • [SW|Domains]

  • [SW|HTH marR-type domain] (aa 33-166) (according to UniProt)

    • Structure

  • [PDB|3CDH] (from Silicibacter pomeroyi, 24% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]-[gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ]
    description
    [Pubmed|25733610]

    sigma factors

  • [protein|1968743631A20739B5DA8B489CB1E7E42F3B93E3|TyrZ]: sigma factor, [Pubmed|1735721], in [regulon|1968743631A20739B5DA8B489CB1E7E42F3B93E3|TyrZ regulon]

    • regulatory mechanism

  • [protein|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|DtrR]: repression, [Pubmed|25733610], in [regulon|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|DtrR regulon]
  • [regulon|T-box|T-box]: anti-termination, in [regulon|T-box|T-box]

    • regulation

  • induced by tyrosine limitation ([protein|search|T-box]) [Pubmed|25733610,19258532,1735721]
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    Biological materials

    Mutant

  • MGNA-B219 (ywaE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1218 NBRP B. subtilis, Japan]
  • BKE38450 ([gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTTAGGCCTGCCTTA, downstream forward: _UP4_GCTGACAATCTTCATACAAC
  • BKK38450 ([gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTTTTAGGCCTGCCTTA, downstream forward: _UP4_GCTGACAATCTTCATACAAC

    • References

  • 25733610