ald [Sun Oct 25 2015 17:51:32 GMT+0100 (CET)]

L-alanine dehydrogenase

locus: BSU31930

pI: 5.00

mw: 39.00 kDa

function: alanine utilization

product: L-alanine dehydrogenase

essential: no

ec: 1.4.1.1

synonyms: spoVN

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.7|Utilization of alanine/ serine]

[SW|Categories] containing this gene/protein

• [SW|utilization of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|AdeR regulon]

Gene

Phenotypes of a mutant

• [SW|sporulation] defect [Pubmed|22797752]

The protein

Catalyzed reaction/ biological activity

• L-alanine H₂O NAD = pyruvate NH₃ NADH (according to Swiss-Prot)

Protein family

• AlaDH/PNT family (according to Swiss-Prot)

[SW|Cofactors]

• NADH [Pubmed|26202482]

Structure

• [PDB|2EEZ] (from ''Thermus thermophilus hb8 mutant'', 55% identity, 66% similarity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|ald]'' [Pubmed|8226620]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8226620]

Regulation

• induced by alanine ([protein|search|AdeR]) [Pubmed|22797752,8226620]

Regulatory mechanism

• [protein|search|AdeR]: transcription activation [Pubmed|22797752]

References

• 19114526,9168598,17183219,8226620,22797752,26202482