alanine-anticapsin ligase
function
biosynthesis of the antibiotic bacilysin
product
alanine-anticapsin ligase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds][SW|Categories] containing this gene/protein
[SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CodY regulon], [SW|ScoC regulon]Gene
Coordinates on the chromosome (coding sequence)
3,870,668 -> 3,872,086
Phenotypes of a mutant
a ''bacD'' point mutation has been isolated upon selction at low pressure [Pubmed|26296725]The protein
Catalyzed reaction/ biological activity
ligation of anticapsin to L-Ala to form bacilysin, ultimate step in bacilysin biosynthesis [Pubmed|23317005]Structure
[PDB|3VMM] [Pubmed|22407814]Expression and Regulation
Operon
''[protein|search|bacA]-[protein|search|bacB]-[protein|search|bacC]-[protein|search|bacD]-[protein|search|bacE]-[protein|search|bacF]'' [Pubmed|12372825][SW|Sigma factor]
[protein|search|SigA] [Pubmed|19801406]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12372825,21709425][protein|search|AbrB]: transcription repression [Pubmed|12697329,21709425][protein|search|ScoC]: transcription repression [Pubmed|19801406]References
16030213,12372825,19352016,19801406,21948839,22407814,24702628,23317005,12697329,21709425,22298000,26296725 
