yqgS

polyglycerolphosphate lipoteichoic acid synthase

locus: BSU_24840

pI: 4.82

mw: 73.03 kDa

protein length: 638 aa

gene length: 1917 bp

function: biosynthesis of lipoteichoic acid

product: minor lipoteichoic acid synthase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.3|Biosynthesis of lipoteichoic acid]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.2|Biosynthesis of lipoteichoic acid]

Gene

Coordinates: 2,568,573 2,570,489

The protein

Protein family

• [SW|LTA synthase family] (according to UniProt)

Paralogous protein(s)

• [protein|418900B6DBDF3EF300C930B0C75E31B939F3CE00|LtaS], [protein|880C655DC7149F6EDC21BD2CF8F9F2C9FBEB2CDB|YvgJ], [protein|CCD06F344E3C87E77C3D13883CE2B927F372A84E|YfnI]

Modification

• can be phosphorylated by [protein|23FF4A00C36EC1B7297F51A9EF3579B41F0B7EBA|PrkC] in vitro [pubmed|30478337]

Structure

• [PDB|2W5Q] ([protein|418900B6DBDF3EF300C930B0C75E31B939F3CE00|LtaS] from S. aureus, corresponds to aa 218 ... 617 of [protein|2B33F2F9C2FB0767B72A29D060037393C88ACEE5|YqgS]) [pubmed|19168632]

[SW|Localization]

• localizes to the division septum [Pubmed|19229300]

Expression and Regulation

Operons

• genes: [gene|89C51789FBB2EE86771ABD8629FD99748ED5D4EF|yqgP]-[gene|C44F6723A2F1A627A0B9042871A07F5365D6121A|yqgO]-[gene|8E10A8B566BC25CBDDEF1503656A4234FD29ACB8|glcK]-[gene|2B33F2F9C2FB0767B72A29D060037393C88ACEE5|yqgS]
  description: [pubmed|22383849]

  additional information

  • [protein|638D6D2FCCA2A167EFED05CB4E60C2D78D5319AE|PhoP]∼P binds to the promoter region, but regulation has not been explored [pubmed|25666134]

Biological materials

Mutant

• MGNA-C419 (yqgS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2417 NBRP B. subtilis, Japan]
• BKE24840 ([gene|2B33F2F9C2FB0767B72A29D060037393C88ACEE5|yqgS]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE24840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCAACCTCCTATGCAG, downstream forward: _UP4_TAATCACAATGTCTCCCGCA
• BKK24840 ([gene|2B33F2F9C2FB0767B72A29D060037393C88ACEE5|yqgS]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK24840 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTTCAACCTCCTATGCAG, downstream forward: _UP4_TAATCACAATGTCTCCCGCA

References

Reviews

• Additional reviews:''' [Pubmed|21255102]
• 21388439

Original publications

• 19229300,21255105,23103977,19168632,30478337