txpA [Sat Jan 28 2017 12:56:38 GMT+0100 (CET)]

toxic peptide, eliminates defective cells from developing biofilms

Locus: BSU26050

Isoelectric point: 8.00

Molecular weight: 6.00 kDa

Function: toxin

Product: toxic peptide

Essential: no

Synonyms: yqcR

Genomic Context

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Categories containing this gene/protein

• Lifestyles → Coping with stress → Toxins, antitoxins and immunity against toxins
• Lifestyles → Coping with stress → Toxins, antitoxins and immunity against toxins → Type 1 TA systems
• Prophages and mobile genetic elements → Prophages → Skin element
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• toxins, antitoxins and immunity against toxins, Skin element, membrane proteins

This gene is a member of the following regulons

• ratA regulon, Spo0A regulon

Gene

Coordinates on the chromosome (coding sequence): 2,678,240 -> 2,678,419

The protein

Catalyzed reaction/ biological activity

• part of a type I toxin/antitoxin system (with RatA) PubMed
• eliminates defective cells from developing biofilms PubMed

Localization

• cell membrane

Expression and Regulation

Operon

• txpA PubMed

Sigma factor

• SigA PubMed

Regulation

• induced by amino acid limitation PubMed

Regulatory mechanism

• Spo0A: transcription activation PubMed
• expression is prevented by the ratA antisense RNA PubMed
• the txpA mRNA-RatA RNA duplex is degraded by [rnc|search|RNase III] PubMed

Additional information

• next to 'yonT', the 'txpA' mRNA has the strongest Shine-Dalgarno region in 'B. subtilis' PubMed

Labs working on this gene/protein

• Richard Losick, Harvard University, Cambridge, USA Homepage

References

Reviews

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Original publications

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