txpA [Thu Aug 04 2016 17:32:11 GMT+0200 (CEST)]

toxic peptide

locus: BSU26050

pI: 8.00

mw: 6.00 kDa

function: toxin

product: toxic peptide

essential: no

synonyms: yqcR

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
• [category|SW 5|Prophages and mobile genetic elements] → [category|SW 5.1|Prophages] → [category|SW 5.1.3|Skin element]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|toxins, antitoxins and immunity against toxins], [SW|Skin element], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|ratA regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,678,240 -> 2,678,419

The protein

[SW|Localization]

• cell membrane

Expression and Regulation

Operon

• ''txpA'' [Pubmed|16166525]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16166525]

Regulatory mechanism

• expression is prevented by the ''[protein|search|ratA]'' antisense RNA [Pubmed|16166525]
• the ''[protein|search|txpA]'' mRNA-''[protein|search|RatA]'' RNA duplex is degraded by [rnc|search|RNase III] [Pubmed|23300471]

Additional information

• next to '[protein|search|yonT]', the '[protein|search|txpA]' mRNA has the strongest Shine-Dalgarno region in 'B. subtilis' [PubMed|19210617]

Labs working on this gene/protein

• [SW|Richard Losick], Harvard University, Cambridge, USA [http://www.mcb.harvard.edu/Losick/ Homepage]

References

Reviews

• 23300472

Original publications

• 16166525,19210617,23300471