function
purine biosynthesis
product
adenylsuccinate lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.9|Newly identified competence genes][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
700,232 -> 701,527
The protein
Catalyzed reaction/ biological activity
N(6)-(1,2-dicarboxyethyl)AMP = fumarate AMP (according to Swiss-Prot)Protein family
Adenylosuccinate lyase subfamily (according to Swiss-Prot)Structure
[PDB|1F1O]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]Expression and Regulation
Operon
''[protein|search|purE]-[protein|search|purK]-[protein|search|purB]-[protein|search|purC]-[protein|search|purS]-[protein|search|purQ]-[protein|search|purL]-[protein|search|purF]-[protein|search|purM]-[protein|search|purN]-[protein|search|purH]-[protein|search|purD]'' [Pubmed|3036807][SW|Sigma factor]
[protein|search|SigA] [Pubmed|3036807]Regulation
repressed in the presence of purine nucleotides ([protein|search|PurR]) [Pubmed|7638212]repressed in the presence of adenine or adenosine([protein|search|PurR]) [Pubmed|2536750]repressed in the presence of guanine([protein|search|G-box]) [Pubmed|3036807]Regulatory mechanism
[PurR]]: transcription repression [Pubmed|7638212][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|2536750][protein|search|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [http://www.ncbi.nlm.nih.gov/sites/entrez/3036807 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/12787499 PubMed2]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids= 17981983 PubMed]belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]References
1722815,3036807,12923093,15378759,7638212 
