ntdC [2017-8-11 16:0:3]

NAD-dependent glucose-6-phosphate dehydrogenase

locus: BSU10530

pI: 6.23

mw: 39.14 kDa

protein length: 350 aa

gene length: 1050 bp

function: synthesis of the antibiotic kanosamine

product: NAD-dependent glucose-6-phosphate dehydrogenase

essential: no

synonyms: yhjJ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]

Gene

Coordinates: 1,126,400 → 1,127,452

The protein

Catalyzed reaction/ biological activity

• glucose-6-phosphate + NAD -→ 3-oxo-d-glucose-6-phosphate + NADH(2) [Pubmed|23586652]

Protein family

• gfo/idh/mocA family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|03BE6DA854612B3F6741E0E167AB310F0DE96285|YfiI], [protein|942BAE9FA023DFCA06B6D26A856A72F2979E23FA|YrbE], [protein|484D17480DFAD3667E0EBC6D38854A7546A8DB46|YteT], [protein|920C5750CB95102B073C32874D512E8D636D2C7D|IolU], [protein|7DFE74C751A67CCC84579D52005E1399B0A10166|IolW], [protein|AA7DCEFB17FD6F9C4F65235E9A247A6EC2242B06|IolX], [protein|93C1DF93CAFC5AE726523A91A3BA7470017FF6DC|IolG]

[SW|Cofactors]

• NAD(+) [Pubmed|23586652]

Expression and Regulation

Operons

• genes: [gene|2F850E2DFA6287DB3890243803E06FDE7ACDB10E|ntdA]-[gene|A4DE6C394B64813A732255734758403241FFAC2F|ntdB]-[gene|29DAF5343A42EAD8DB97925FE7D049410F7B7FCA|ntdC]-[gene|ADB476B0B385D9B9CAF02902CE115C8309F67911|glcP]
  description: [Pubmed|17056753]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|14612444], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|NtdR]: activation, in [regulon|9118A36CD30E7C99697B3659BB04E03BB7EE71D7|NtdR regulon]

  regulation

  • induced by 3,3'-neotrehalosadiamine ([protein|search|NtdR]) [Pubmed|14612444]

Biological materials

Mutant

• MGNA-B286 (yhjJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1285 NBRP B. subtilis, Japan]

References

Reviews

• 21512256

Original publications

• 19087206,17056753,14612444,23586652,28353336