ntdC [2017-8-11 16:0:3]

NAD-dependent glucose-6-phosphate dehydrogenase

Locus: BSU10530

Isoelectric point: 6.23

Molecular weight: 39.14 kDa

Protein length: 350 aa

Gene length: 1050 bp

Function: synthesis of the antibiotic kanosamine

Product: NAD-dependent glucose-6-phosphate dehydrogenase

Essential: no

Synonyms: yhjJ

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

Gene

Coordinates: 1,126,400 → 1,127,452

The protein

Catalyzed reaction/ biological activity

• glucose-6-phosphate + NAD -→ 3-oxo-d-glucose-6-phosphate + NADH(2) PubMed

Protein family

• gfo/idh/mocA family (according to Swiss-Prot)

Paralogous protein(s)

• YfiI, YrbE, YteT, IolU, IolW, IolX, IolG

Cofactors

• NAD(+) PubMed

Expression and Regulation

Operons

• Genes: ntdA-ntdB-ntdC-glcP
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • NtdR: activation, in NtdR regulon

  Regulation

  • induced by 3,3'-neotrehalosadiamine (NtdR) PubMed

Biological materials

Mutant

• MGNA-B286 (yhjJ::erm), available at the NBRP B. subtilis, Japan

References

Reviews

Loading

Original publications

Loading