thrB [Mon Jun 06 2016 13:08:36 GMT+0200 (CEST)]

homoserine kinase

locus: BSU32240

pI: 4.00

mw: 33.00 kDa

function: biosynthesis of threonine

product: homoserine kinase

essential: no

ec: 2.7.1.39

synonyms: thrA

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

This gene is a member of the following [SW|regulons]

• [SW|CodY regulon], [SW|ThrR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,312,844 -> 3,313,773

The protein

Catalyzed reaction/ biological activity

• ATP L-homoserine = ADP O-phospho-L-homoserine (according to Swiss-Prot)

Protein family

• Homoserine kinase subfamily (according to Swiss-Prot)

Structure

• [PDB|3HUL] (from ''Listeria monocytogenes'', 41% identity, 61% similarity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|hom]-[protein|search|thrC]-[protein|search|thrB]'' [Pubmed|12107147]

Regulation

• repressed by casamino acids [Pubmed|12107147]
• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|24163341]

Regulatory mechanism

• [protein|search|CodY]: transcription repression [Pubmed|24163341]
• [protein|search|ThrR]: transcription repression [Pubmed|27260660]

References

• 12107147,3098560,24163341,27260660