mneP [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

primary manganese (II) efflux pump

locus: BSU05470

pI: 6.00

mw: 32.00 kDa

function: Mn(II) export

product: manganese (II) efflux pump

essential: no

synonyms: ydfM

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.13|Metal ion exporters]
• [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.2|Manganese]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|MntR regulon]

Gene

Coordinates on the chromosome (coding sequence): 595,109 -> 596,002

Phenotypes of a mutant

• sensitive to Mn(II) [Pubmed|27748968]

The protein

Catalyzed reaction/ biological activity

• efflux of Mn(II) [Pubmed|27748968]

Protein family

• cation diffusion facilitator (CDF) family [Pubmed|27748968]

Expression and Regulation

Operon

• ''[SW|mneP]'' [Pubmed|22383849]

[SW|Sigma factor]

• [SW|SigA] [Pubmed|27748968]

Regulation

• expressed at elevated Mn(II) concentrations ([SW|MntR]) [Pubmed|27748968]

Regulatory mechanism

• [SW|MntR]: transcription activation [Pubmed|27748968]

References

• 27748968