function
glucomannan utilization
product
beta-1,4-mannanase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.25|Utilization of glucomannan][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GmuR regulon]Gene
Coordinates on the chromosome (coding sequence)
632,774 -> 633,862
The protein
Catalyzed reaction/ biological activity
Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans (according to Swiss-Prot)Protein family
glycosyl hydrolase 26 family (according to Swiss-Prot)Structure
[PDB|2QHA], [http://www.proteopedia.org/wiki/index.php/3cbw 3CBW] mutant variant[SW|Localization]
extracellular (signal peptide) [Pubmed|18957862]Expression and Regulation
Operon
''[protein|search|gmuB]-[protein|search|gmuA]-[protein|search|gmuC]-[protein|search|gmuD]-[protein|search|gmuR]-[protein|search|gmuE]-[protein|search|gmuF]-[protein|search|gmuG]'' [Pubmed|18177310][SW|Sigma factor]
[protein|search|SigA] [Pubmed|18177310]Regulation
induced by conjac glucomannan (requires [protein|search|GmuG]) ([protein|search|GmuR]) [Pubmed|18177310]induced by cellobiose ([protein|search|GmuR]) [Pubmed|18177310]subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|18177310]Regulatory mechanism
[protein|search|GmuR]: transcription repression [Pubmed|18177310][protein|search|CcpA]: transcription repression [Pubmed|18177310][protein|search|AbrB]: transcription activation [Pubmed|20817675]References
19504356,18177310,18957862,19441796,20709850,20817675,24421132 
