response regulator aspartate phosphatase, dephosphorylates Spo0F-P, control of the phosphorelay
function
control of sporulation initiation
product
response regulator aspartate phosphatase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay] → [category|SW 3.4.7.5|Phosphatases controlling the phosphorelay][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay] → [category|SW 4.2.2.5|Phosphatases controlling the phosphorelay][SW|Categories] containing this gene/protein
[SW|protein modification], [SW|transcription factors and their control], [SW|phosphorelay], [SW|quorum sensing]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|ComA regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,315,869 -> 1,317,005
The protein
Protein family
RAP family (according to Swiss-Prot)[SW|Domains]
modular organization comprising an amino terminal alpha-helical domain connected to a domain formed by six tetratricopeptide (TPR) repeats [Pubmed|11923303,22267516][SW|Interactions]
[protein|search|RapA] (central TPR3-5 repeats) -[protein|search|PhrA] [Pubmed|11923303,22267516][protein|search|RapA] (N-terminal 60 amino acids) -[SW|Spo0F] [Pubmed|11923303,22267516]Expression and Regulation
Operon
''[protein|search|rapA]-[protein|search|phrA]'' [Pubmed|1378051][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1378051]Regulation
repressed by glucose (4.2-fold) ([protein|search|CcpA]) [Pubmed|12850135]repressed by casamino acids [Pubmed|12107147]repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]Regulatory mechanism
[protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051][protein|search|CcpA]: transcription repression [Pubmed|12850135][SW|Spo0A]: transcription repression [Pubmed|14651647][protein|search|CodY]: transcription repression [Pubmed|23569278,12618455]References
8643670,8730857,11923303,22267516,14651647,12618455,12107147,19380751,12850135,1378051,16091051,23569278,26582911 
