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sqhC
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sqhC

squalene-hopene cyclase, biosynthesis of sporulenes, protection of the spore against oxidative stress
Locus
BSU_19320
Isoelectric point
7.63
Molecular weight
71.05 kDa
Protein length
632 aa Sequence Blast
Gene length
1899 bp Sequence Blast
Function
biosynthesis of sporulenes
Product
squalene-hopene cyclase
Essential
no
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,102,168 2,104,066

The protein

Catalyzed reaction/ biological activity

  • sporulenol --> H2O + tetraprenyl-β-curcumene (according to UniProt)
  • production of sporulenes, polycyclic terpenoid lipids PubMed
  • protection of the spore against oxidative stress PubMed
  • Protein family

  • terpene cyclase/mutase family (single member, according to UniProt)
  • Structure

  • 2SQC (from Alicyclobacillus acidocaldarius, 32% identity) PubMed
  • Localization

  • surrounds the forespores PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigE: sigma factor, PubMed, in SigE regulon
  • Regulation

  • expressed during sporulation in the mother cell PubMed
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    Biological materials

    Mutant

  • BKE19320 (sqhC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCACGCTCAACTCCTTCA, downstream forward: _UP4_GATTCTATTGAAAAGGAGAC
  • BKK19320 (sqhC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCACGCTCAACTCCTTCA, downstream forward: _UP4_GATTCTATTGAAAAGGAGAC
  • References

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