lysS

lysyl-tRNA synthetase

Locus: BSU_00820

Isoelectric point: 5.03

Molecular weight: 57.37 kDa

Protein length: 499 aa

Gene length: 1500 bp

Function: translation

Product: lysyl-tRNA synthetase

Essential: yes

E.C.: 6.1.1.6

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
• Groups of genes → Essential genes

Gene

Coordinates: 88,727 90,226

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + L-lysine + tRNA^Lys --> AMP + diphosphate + L-lysyl-tRNA^Lys (according to UniProt)

Protein family

• Class-II aminoacyl-tRNA synthetase family (according to UniProt)

Structure

• 2E9I (from Geobacillus stearothermophilus, in complex with L-Lysine hydroxamate-AMP) PubMed

Localization

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• Genes: lysS
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

• Genes: pabB-pabA-pabC-sul-folB-folK-yazB-yacF-lysS
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulation

  • translation repressed by tryptophan (MtrB) PubMed

References

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