ATP-dependent DNA helicase, branch migration translocase, required for DNA repair and chromosomal segregation
function
DNA repair and chromosomal segregation
product
ATP-dependent DNA helicase, branch migration translocase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]Gene
Coordinates
1,659,810 → 1,661,858
Phenotypes of a mutant
a [gene|A3D05FE662CCCFE79B3CB38486206413B84E5D80|recD2] [gene|24B1C2A663A5B7C45940272595868F9F05A04A7B|recG] double mutant is not viable [pubmed|28527403]The protein
Catalyzed reaction/ biological activity
binds and unwinds Holliday junction DNA [Pubmed|24770420]Protein family
helicase C-terminal domain (according to Swiss-Prot)Paralogous protein(s)
[protein|AD1F39823ABCE2A222259B879513752942C59590|Mfd]Structure
[PDB|1GM5] (from ''Thermotoga maritima'', 43% identity, 62% similarity)Expression and Regulation
Operons
genes
[gene|BC19D5B3764503298ED7136FC9F63A68F6AC464F|sdaAB]-[gene|8361D87307D2E8350945F592ABD24E2109E2E81A|sdaAA]-[gene|24B1C2A663A5B7C45940272595868F9F05A04A7B|recG]
description
[Pubmed|22383849]
view in new tabBiological materials
Mutant
1A897 (no resistance), [Pubmed|16020779], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A897&Search=1A897 BGSC]BKE15870 (Δ[gene|24B1C2A663A5B7C45940272595868F9F05A04A7B|recG]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCCAATACCCTTAATGTTAG, downstream forward: _UP4_TGAGTATCAGAAGTTTTTGGBKK15870 (Δ[gene|24B1C2A663A5B7C45940272595868F9F05A04A7B|recG]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15870 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCCAATACCCTTAATGTTAG, downstream forward: _UP4_TGAGTATCAGAAGTTTTTGGReferences
17853894,15533834,17640277,24770420,21170359,28527403