bsrG [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane invaginations together with delocalization of the cell wall synthesis machinery, triggers autolysis, and inhibits protein biosynthesis

locus: new_2273515_2273748

pI: 0.00

mw: 0.00 kDa

function: stability of prophage SPß

product: hydrophobic class I toxin

essential: no

synonyms: bsrG,S809

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]

[SW|Categories] containing this gene/protein

• [SW|toxins, antitoxins and immunity against toxins], [SW|SP-beta prophage], [SW|membrane proteins]

Gene

Coordinates on the chromosome: 2,273,515 -> 2,273,748

Protein

[SW|Localization]

• membrane protein (based on the presence of a trans-membrane domain) [Pubmed|22229825]

Expression and Regulation

Operon

• ''[SW|bsrG]'' [Pubmed|22229825]

Sigma factor

• [SW|SigA] [Pubmed|22229825]

Regulation

• expression increases at the onset of the stationary phase [Pubmed|22229825]
• the mRNA is destabilized upon interaction with the antitoxin RNA [protein|search|SR4] [Pubmed|22229825]
• the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr] [Pubmed|22229825]

Regulatory mechanism

• the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr], degradation is enhanced at higher temperature [Pubmed|22229825]

Additional information

• half-life of the mRNA: 15 min [Pubmed|22229825]

Labs working on this gene/protein

• [SW|Sabine Brantl], Jena, Germany

References

Original publications

• 18948176,20525796,23969414,22229825,26234942,26802042